Article
Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307.
Antimicrobial agents and chemotherapy - 1 May 2009
De Palma Armando M, Thibaut Hendrik Jan, van der Linden Lonneke, Lanke Kjerstin, Heggermont Ward, Ireland Stephen, Andrews Robert, Arimilli Murty, Al-Tel Taleb H, De Clercq Erik, van Kuppeveld Frank, Neyts Johan
Abstract excerpt
A novel compound, TTP-8307, was identified as a potent inhibitor of the replication of several rhino- and enteroviruses. TTP-8307 inhibits viral RNA synthesis in a dose-dependent manner, without affecting polyprotein synthesis and/or processing. Drug-resistant variants of coxsackievirus B3 were all shown to carry at least one amino acid mutation in the nonstructural protein 3A. In particular, three mutations...
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