Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Attenuated virulence of pleconaril-resistant coxsackievirus B3 variants.

The Journal of infectious diseases - 1 Jun 1999

Groarke J M, Pevear D C

Abstract excerpt

Pleconaril (VP 63843) is a novel orally bioavailable small molecule with broad antipicornavirus (enterovirus and rhinovirus) activity. Ten independently derived pleconaril-resistant variants of coxsackievirus B3 were isolated from cell culture. The molecular basis of drug resistance and the biologic properties of the drug-resistant viruses were investigated. RNA sequence analysis revealed amino acid changes in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Capsid
Share to Capsid Proteins
Share to Drug Resistance, Microbial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enterovirus B, Human

Share to Mice, Inbred BALB C

Share to Oxadiazoles

Share to Oxazoles

Share to Sequence Analysis, RNA

Source

Identifiers

PMID: 10228078
DOI: 10.1086/314758

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Attenuated virulence of pleconaril-resistant coxsackievirus B3 variants.PMID 10228078Read ↗

New pleconaril and [(biphenyloxy)propyl]isoxazole derivatives with substitutions in the central ring exhibit antiviral activity against pleconaril-resistant coxsackievirus B3.Semantic proximity Read ↗

Molecular mechanism of rhinovirus escape from the Pyrazolo[3,4-d]pyrimidine capsid-binding inhibitor OBR-5-340 via mutations distant from the binding pocket: Derivatives that brake resistance.Semantic proximity Read ↗

VP1 Sequencing of All Human Rhinovirus Serotypes:Insights into Genus Phylogeny and Susceptibility to AntiviralCapsid-BindingCompoundsSemantic proximity Read ↗

New class of early-stage enterovirus inhibitors with a novel mechanism of action.Semantic proximity Read ↗

Characterization of poliovirus variants selected for resistance to the antiviral compound V-073.Semantic proximity Read ↗

Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307.Semantic proximity Read ↗

Comparative analysis of the molecular mechanism of resistance to vapendavir across a panel of picornavirus speciesSemantic proximity Read ↗

A novel benzonitrile analogue inhibits rhinovirus replication.Semantic proximity Read ↗

Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral.Semantic proximity Read ↗

New small-molecule inhibitors effectively blocking picornavirus replication.Semantic proximity Read ↗

Coronaviruses Resistant to a 3C-Like Protease Inhibitor Are Attenuated for Replication and Pathogenesis, Revealing a Low Genetic Barrier but High Fitness Cost of ResistanceSemantic proximity Read ↗

In vitro resistance profile of the hepatitis C virus NS3 protease inhibitor BI 201335.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.