Article
Stress-induced mutagenesis in bacteria.
Science (New York, N.Y.) - 30 May 2003
Bjedov Ivana, Tenaillon Olivier, Gérard Bénédicte, Souza Valeria, Denamur Erick, Radman Miroslav, Taddei François, Matic Ivan
Abstract excerpt
The evolutionary significance of stress-induced mutagenesis was evaluated by studying mutagenesis in aging colonies (MAC) of Escherichia coli natural isolates. A large fraction of isolates exhibited a strong MAC, and the high MAC variability reflected the diversity of selective pressures in ecological niches. MAC depends on starvation, oxygen, and RpoS and adenosine 3',5'-monophosphate regulons; thus it may be a...
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