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Article

Clinical significance of genetic aberrations in secondary acute myeloid leukemia.

American journal of hematology - 1 Nov 2012

Milosevic Jelena D, Puda Ana, Malcovati Luca, Berg Tiina, Hofbauer Michael, Stukalov Alexey, Klampfl Thorsten, Harutyunyan Ashot S, Gisslinger Heinz, Gisslinger Bettina, Burjanivova Tatiana, Rumi Elisa, Pietra Daniela, Elena Chiara, Vannucchi Alessandro M, Doubek Michael, Dvorakova Dana, Robesova Blanka, Wieser Rotraud, Koller Elisabeth, Suvajdzic Nada, Tomin Dragica, Tosic Natasa, Colinge Jacques, Racil Zdenek, Steurer Michael, Pavlovic Sonja, Cazzola Mario, Kralovics Robert

Abstract excerpt

The study aimed to identify genetic lesions associated with secondary acute myeloid leukemia (sAML) in comparison with AML arising de novo (dnAML) and assess their impact on patients' overall survival (OS). High-resolution genotyping and loss of heterozygosity mapping was performed on DNA samples from 86 sAML and 117 dnAML patients, using Affymetrix Genome-Wide Human SNP 6.0 arrays. Genes TP53, RUNX1, CBL,...

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Source

Identifiers

PMID: 22887079
DOI: 10.1002/ajh.23309

Genes

CUX1
FLT3
NPM1
CBL
ETV6
FOXP1
IDH1
IKZF1
NRAS
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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