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Article

Proteome-Wide Mendelian Randomization Implicates Shared Necroptosis-Ferroptosis Effectors in Causal Pathways of Multiple Sclerosis Susceptibility.

Annals of the New York Academy of Sciences - 1 Feb 2026

Yan Wu, Jianhong Wang, Wen Jiang, Linming Zhang

Abstract excerpt

Multiple sclerosis (MS) is a chronic neurodegenerative disorder for which dysregulated ferroptosis and necroptosis have demonstrated pathological associations but these lack causal validation in disease susceptibility. This study employed proteome-wide Mendelian randomization (MR) to investigate causal links between ferroptosis/necroptosis pathways, their upstream regulators, immune interactions, and MS risk....

Topics

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Ferroptosis
CFB gene
CP gene
Genetic Predisposition to Disease
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multiple Sclerosis

Tumor Necrosis Factor alpha-Induced Protein 3

Source

Identifiers

PMID: 41387240
DOI: 10.1111/nyas.70162

Genes

IFNA4
TNFAIP3
APOE
CA6
CFB
CP
GZMA
KIR2DL2
CD27
CXCL3
KIR2DL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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