Genetic association of GABA-A receptor alpha-2 and mu opioid receptor with cocaine cue-reactivity: evidence for inhibitory synaptic neurotransmission involvement in cocaine dependence.

Abstract excerpt

BACKGROUND: This pilot feasibility study examined the role of genetics in laboratory-induced cocaine craving. METHODS: Thirty-four African American, cocaine-depend- ent male subjects underwent a baseline assessment, cue-exposure session, and genetic analysis. Subjects were classified as either cue-reactive or nonreactive. RESULTS: Among single nucleotide polymorphism markers in 13 candidate genes examined for...

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