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Article

The PNPLA3-I148M variant increases polyunsaturated triglycerides in human adipose tissue.

Liver international : official journal of the International Association for the Study of the Liver - 1 Sept 2020

Qadri Sami, Lallukka-Brück Susanna, Luukkonen Panu K, Zhou You, Gastaldelli Amalia, Orho-Melander Marju, Sammalkorpi Henna, Juuti Anne, Penttilä Anne K, Perttilä Julia, Hakkarainen Antti, Lehtimäki Tiina E, Orešič Matej, Hyötyläinen Tuulia, Hodson Leanne, Olkkonen Vesa M, Yki-Järvinen Hannele

Abstract excerpt

BACKGROUND & AIMS: The I148M variant in PNPLA3 is the major genetic risk factor for non-alcoholic fatty liver disease (NAFLD). The liver is enriched with polyunsaturated triglycerides (PUFA-TGs) in PNPLA3-I148M carriers. Gene expression data indicate that PNPLA3 is liver-specific in humans, but whether it functions in adipose tissue (AT) is unknown. We investigated whether PNPLA3-I148M modifies AT metabolism in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32386450
DOI: 10.1111/liv.14507

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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