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Article

Characterization of virulence-associated determinants in the envelope glycoprotein of Pichinde virus.

Virology - 10 Nov 2012

Kumar Naveen, Wang Jialong, Lan Shuiyun, Danzy Shamika, McLay Schelde Lisa, Seladi-Schulman Jill, Ly Hinh, Liang Yuying

Abstract excerpt

We use a small animal model, based on guinea pigs infected with a non-pathogenic Pichinde virus (PICV), to understand the virulence mechanisms of arenavirus infections in the hosts. PICV P2 strain causes a mild febrile reaction in guinea pigs, while P18 causes severe disease with clinical and pathological features reminiscent of Lassa hemorrhagic fever in humans. The envelope glycoproteins (GPC) of P2 and P18...

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Source

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Identifiers

PMID: 22877842
DOI: 10.1016/j.virol.2012.07.009
PMCID: PMC3444631

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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