Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sequence analysis of the small RNA segment of guinea pig-passaged Pichinde virus variants.

The American journal of tropical medicine and hygiene - 1 Aug 1999

Zhang L, Marriott K, Aronson J F

Abstract excerpt

The established animal model for Lassa fever is based on the new world arenavirus Pichinde (PIC). Natural isolates of PIC virus are attenuated in guinea pigs, but serial guinea pig passage renders them extremely virulent in that host. We have compared the nucleotide sequences of the small RNA segments of two attenuated, low-passage variants of the PIC virus Munchique strain (CoAn 4763) and two virulent,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA
Share to Codon
Share to Guinea Pigs

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lethal Dose 50

Share to Models, Genetic

Share to Mutation, Missense

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to Sequence Analysis, RNA

Source

Identifiers

PMID: 10463670
DOI: 10.4269/ajtmh.1999.61.220

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sequence analysis of the small RNA segment of guinea pig-passaged Pichinde virus variants.PMID 10463670Read ↗

Reassortant analysis of guinea pig virulence of pichinde virus variants.Semantic proximity Read ↗

Characterization of virulence-associated determinants in the envelope glycoprotein of Pichinde virus.Semantic proximity Read ↗

Characterization of the Glycoprotein Stable Signal Peptide in Mediating Pichinde Virus Replication and Virulence.Semantic proximity Read ↗

Molecular characterization of guinea pig-adapted variants of Ebola virus.Semantic proximity Read ↗

An attenuated Machupo virus with a disrupted L-segment intergenic region protects guinea pigs against lethal Guanarito virus infectionSemantic proximity Read ↗

The roles of XJ13 and XJ44-specific mutations within the Candid #1 GPC in Junin virus attenuation.Semantic proximity Read ↗

Development of Infectious Clones for Virulent and Avirulent Pichinde Viruses: a Model Virus To Study Arenavirus-Induced Hemorrhagic FeversSemantic proximity Read ↗

Genomic changes in an attenuated genotype I Japanese encephalitis virus and comparison with virulent parental strain.Semantic proximity Read ↗

A Wild-Type Porcine Encephalomyocarditis Virus Containing a Short Poly(C) Tract Is Pathogenic to Mice, Pigs, and Cynomolgus MacaquesSemantic proximity Read ↗

Mutations in the genome of the highly pathogenic porcine reproductive and respiratory syndrome virus potentially related to attenuation.Semantic proximity Read ↗

Elucidating variations in the nucleotide sequence of Ebola virus associated with increasing pathogenicitySemantic proximity Read ↗

A single amino acid substitution in nonstructural protein 3A can mediate adaptation of foot-and-mouth disease virus to the guinea pig.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.