The Unique Glycosylation at Position 986 on the E2 Glycoprotein of Classical Swine Fever Virus Is Responsible for Viral Attenuation and Protection against Lethal Challenge.

Abstract excerpt

Classical swine fever (CSF) is an economically important disease of pigs caused by classical swine fever virus (CSFV). The live attenuated vaccine C-strain (also called HCLV strain) against CSF was produced by multiple passages of a highly virulent strain in rabbits. However, the molecular determinants for its attenuation and protection remain unclear. In this study, we identified a unique glycosylation at...

Topics

• Animals
• Antibodies, Neutralizing
• Classical Swine Fever
• Classical Swine Fever Virus
• Glycosylation
• Immunization
• Mutation
• Protein Multimerization
• Rabbits
• Swine