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Development of Infectious Clones for Virulent and Avirulent Pichinde Viruses: a Model Virus To Study Arenavirus-Induced Hemorrhagic Fevers

23 Apr 2009

Abstract excerpt

Several arenaviruses can cause hemorrhagic fever diseases (VHFs) in humans, the pathogenic mechanism of which is poorly understood due to their virulent nature and the lack of molecular clones. A safe, convenient, and economical small animal model of arenavirus hemorrhagic fever is based on guinea pigs infected by the arenavirus Pichinde (PICV). PICV does not cause disease in humans, but an adapted strain of PICV...

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PMID: 19386714
DOI: 10.1128/jvi.00019-09

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Development of Infectious Clones for Virulent and Avirulent Pichinde Viruses: a Model Virus To Study Arenavirus-Induced Hemorrhagic FeversPMID 19386714Read ↗

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Identification of a novel biological role of arenavirus NP exonuclease (exoN) activity in a safe Pichinde virus modelSemantic proximity Read ↗

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