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Identification of Virulence Determinants within the L Genomic Segment of the Pichinde Arenavirus

4 Apr 2013

Abstract excerpt

Several arenaviruses are responsible for causing viral hemorrhagic fevers (VHF) in humans. Lassa virus (LASV), the causative agent of Lassa fever, is a biosafety level 4 (BSL4) pathogen that requires handling in BSL4 facilities. In contrast, the Pichinde arenavirus (PICV) is a BSL2 pathogen that can cause hemorrhagic fever-like symptoms in guinea pigs that resemble those observed in human Lassa fever. Comparative...

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PMID: 23552411
DOI: 10.1128/jvi.00044-13

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