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Article

An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics.

Nature cell biology - 1 Sept 2009

Mori Daisuke, Yamada Masami, Mimori-Kiyosue Yuko, Shirai Yasuhito, Suzuki Atsushi, Ohno Shigeo, Saya Hideaki, Wynshaw-Boris Anthony, Hirotsune Shinji

Abstract excerpt

Orchestrated remodelling of the cytoskeketon is prominent during neurite extension. In contrast with the extensive characterization of actin filament regulation, little is known about the dynamics of microtubules during neurite extension. Here we identify an atypical protein kinase C (aPKC)-Aurora A-NDEL1 pathway that is crucial for the regulation of microtubule organization during neurite extension. aPKC...

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Source

Identifiers

PMID: 19668197
DOI: 10.1038/ncb1919

Genes

NDEL1
TPX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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