Impact of the cystic fibrosis mutation F508del-CFTR on renal cyst formation and growth.

Abstract excerpt

In autosomal dominant polycystic kidney disease (ADPKD), cystic fibrosis transmembrane conductance regulator (CFTR), the protein product of the gene defective in cystic fibrosis (CF), plays a crucial role in fluid accumulation, which promotes cyst swelling. Several studies have identified individuals afflicted by both ADPKD and CF. Two studies suggested that CF mutations might attenuate the severity of ADPKD,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Proliferation
• Share to Cells, Cultured