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Article

Phosphorothioate Oligonucleotides: Effectiveness and Toxicity

1 Jun 2014

Abstract excerpt

BACKGROUND: Many experimental and clinical studies have focused on the antisense strategy. In this context phosphorothioate oligonucleotides are compounds addressed to hybridize to a targeted mRNA inducing a variety of effects including inhibition of the expression of proteins involved in different pathological processes and preventing translation. METHODS: In this review, we provide an update on clinical...

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PMID: 24655142
DOI: 10.2174/1389450115666140321100304

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