Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of the VKORC1 D36Y variant on warfarin dose requirement and pharmacogenetic dose prediction.

Thrombosis and haemostasis - 1 Oct 2012

Kurnik Daniel, Qasim Husam, Sominsky Sophie, Lubetsky Aharon, Markovits Noa, Li Chun, Stein C Michael, Halkin Hillel, Gak Eva, Loebstein Ronen

Abstract excerpt

Pharmacogenetic dosing algorithms help predict warfarin maintenance doses, but their predictive performance differs in different populations, possibly due to unsuspected population-specific genetic variants. The objectives of this study were to quantify the effect of the VKORC1 D36Y variant (a marker of warfarin resistance previously described in 4% of Ashkenazi Jews) on warfarin maintenance doses and to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to Amino Acid Substitution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Anticoagulants

Share to Dose-Response Relationship, Drug

Share to Israel

Share to Mixed Function Oxygenases

Share to Vitamin K Epoxide Reductases

Share to Warfarin

Source

Open in PubMed Open full text

Identifiers

PMID: 22871975
DOI: 10.1160/TH12-03-0151
PMCID: PMC3461592

Genes

VKORC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of the VKORC1 D36Y variant on warfarin dose requirement and pharmacogenetic dose prediction.PMID 22871975Read ↗

A new warfarin dosing algorithm including VKORC1 3730 G > A polymorphism: comparison with results obtained by other published algorithms.Semantic proximity Read ↗

VKORC1 Asp36Tyr geographic distribution and its impact on warfarin dose requirements in Egyptians.Semantic proximity Read ↗

The Impact of Genetic and Non-Genetic Factors on Warfarin Dose Prediction in MENA Region: A Systematic Review.Semantic proximity Read ↗

Evaluation of 16 genotype-guided Warfarin Dosing Algorithms in 310 Korean Patients Receiving Warfarin Treatment: Poor Prediction Performance in VKORC1 1173C Carriers.Semantic proximity Read ↗

Genetic and nongenetic factors associated with warfarin dose requirements in Egyptian patients.Semantic proximity Read ↗

Validation of a proposed warfarin dosing algorithm based on the genetic make-up of Egyptian patients.Semantic proximity Read ↗

Meta-analysis of genome-wide association studies of stable warfarin dose in patients of African ancestry.Semantic proximity Read ↗

<i>VKORC1</i> Polymorphisms, Haplotypes and Haplotype Groups on Warfarin Dose Among African–Americans and European–AmericansSemantic proximity Read ↗

Warfarin dosing algorithms: A systematic review.Semantic proximity Read ↗

Estimation of the warfarin dose with a pharmacogenetic refinement algorithm in Chinese patients mainly under low-intensity warfarin anticoagulation.Semantic proximity Read ↗

Influence of Genotype on Warfarin Maintenance Dose Predictions Produced Using a Bayesian Dose Individualization Tool.Semantic proximity Read ↗

International warfarin genotype-guided dosing algorithms in the Turkish population and their preventive effects on major and life-threatening hemorrhagic events.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.