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Article

Influence of Genotype on Warfarin Maintenance Dose Predictions Produced Using a Bayesian Dose Individualization Tool.

Therapeutic drug monitoring - 1 Dec 2016

Saffian Shamin M, Duffull Stephen B, Roberts Rebecca L, Tait Robert C, Black Leanne, Lund Kirstin A, Thomson Alison H, Wright Daniel F B

Abstract excerpt

BACKGROUND: A previously established Bayesian dosing tool for warfarin was found to produce biased maintenance dose predictions. In this study, we aimed (1) to determine whether the biased warfarin dose predictions previously observed could be replicated in a new cohort of patients from 2 different clinical settings, (2) to explore the influence of CYP2C9 and VKORC1 genotype on predictive performance of the...

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Source

Identifiers

PMID: 27855133
DOI: 10.1097/FTD.0000000000000347

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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