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Article

Comparison of methods to detect copy number alterations in cancer using simulated and real genotyping data.

BMC bioinformatics - 7 Aug 2012

Mosén-Ansorena David, Aransay Ana María, Rodríguez-Ezpeleta Naiara

Abstract excerpt

BACKGROUND: The detection of genomic copy number alterations (CNA) in cancer based on SNP arrays requires methods that take into account tumour specific factors such as normal cell contamination and tumour heterogeneity. A number of tools have been recently developed but their performance needs yet to be thoroughly assessed. To this aim, a comprehensive model that integrates the factors of normal cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22870940
DOI: 10.1186/1471-2105-13-192
PMCID: PMC3472297

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