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MTHFR rs1801133 C>T polymorphism is associated with an increased risk of tetralogy of Fallot

15 Jan 2014

Abstract excerpt

Abnormal folate metabolism and common variants of folate‑metabolizing enzymes have been described as possible risk factors for congenital heart disease (CHD). Two important folate‑metabolizing enzymes involved in the folate/homocysteine metabolic pathway are 5,10‑methylenetetrahydrofolate reductase (MTHFR) and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1). MTHFR and MTHFD1 polymorphisms may be associated...

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PMID: 24649091
DOI: 10.3892/br.2014.222

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