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Article

Direct Conversion of an Enzyme from Native-like to Amyloid-like Aggregates within Inclusion Bodies.

Biophysical journal - 20 Jun 2017

Elia Francesco, Cantini Francesca, Chiti Fabrizio, Dobson Christopher Martin, Bemporad Francesco

Abstract excerpt

The acylphosphatase from Sulfolobus solfataricus (Sso AcP) is a globular protein able to aggregate in vitro from a native-like conformational ensemble without the need for a transition across the major unfolding energy barrier. This process leads to the formation of assemblies in which the protein retains its native-like structure, which subsequently convert into amyloid-like aggregates. Here, we investigate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inclusion Bodies

Share to Nuclear Magnetic Resonance, Biomolecular

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Share to Protein Aggregation, Pathological

Share to Spectroscopy, Fourier Transform Infrared

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Source

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Identifiers

PMID: 28636911
DOI: 10.1016/j.bpj.2017.05.011
PMCID: PMC5479110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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