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Article

Distinct genetic association at the PLCE1 locus with oesophageal squamous cell carcinoma in the South African population.

Carcinogenesis - 1 Nov 2012

Bye Hannah, Prescott Natalie J, Lewis Cathryn M, Matejcic Marco, Moodley Loven, Robertson Barbara, Rensburg Christo van, Parker M Iqbal, Mathew Christopher G

Abstract excerpt

Oesophageal squamous cell carcinoma (OSCC) has a high prevalence in the Black and Mixed Ancestry populations of South Africa. Recently, three genome-wide association studies in Chinese populations identified five new OSCC susceptibility loci, including variants at PLCE1, C20orf54, PDE4D, RUNX1 and UNC5CL, but their contribution to disease risk in other populations is unknown. In this study, we report testing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22865593
DOI: 10.1093/carcin/bgs262
PMCID: PMC3584964

Genes

PLCE1
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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