Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population.

doi:10.1038/ng.3090

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Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population.

Nature genetics - 1 Oct 2014

Wei Qingyi, Yu Dianke, Liu Mingbo, Wang Mengyun, Zhao Miaoqing, Liu Ming, Jia Weihua, Ma Hongxia, Fang Jugao, Xu Wei, Chen Kexing, Xu Zhengang, Wang Jialing, Tian Linli, Yuan Hua, Chang Jiang, Hu Zhibin, Wei Lixun, Huang Ying, Han Yaling, Liu Jie, Han Demin, Shen Hongbing, Yang Shiming, Zheng Hong, Ji Qinghai, Li Duanshu, Tan Wen, Wu Chen, Lin Dongxin

Abstract excerpt

To identify genetic markers for laryngeal squamous cell carcinoma (LSCC), we conducted a genome-wide association study (GWAS) on 993 individuals with LSCC (cases) and 1,995 cancer-free controls from Chinese populations. The most promising variants (association P < 1 × 10(-5)) were then replicated in 3 independent sets including 2,398 cases and 2,804 controls, among which we identified 3 new susceptibility loci at...

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PMID: 25194280
DOI: 10.1038/ng.3090

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