Association of a deletion of GSTT2B with an altered risk of oesophageal squamous cell carcinoma in a South African population: a case-control study.

doi:10.1371/journal.pone.0029366

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Association of a deletion of GSTT2B with an altered risk of oesophageal squamous cell carcinoma in a South African population: a case-control study.

PloS one - 1 Jan 2011

Matejcic Marco, Li DongPing, Prescott Natalie J, Lewis Cathryn M, Mathew Christopher G, Parker M Iqbal

Abstract excerpt

BACKGROUND: Polymorphisms in the Glutathione S-transferase genes are associated with altered risks in many cancers, but their role in oesophageal cancer is unclear. Recently a 37-kb deletion polymorphism of GSTT2B that reduces expression of GSTT2 has been described. We evaluated the influence of the GSTT1 and GSTT2B deletion polymorphisms, and the GSTP1 Ile105Val polymorphism (rs1695) on susceptibility to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Drinking

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carcinoma, Squamous Cell

Share to Esophageal Neoplasms

Share to Gene Deletion

Share to Glutathione Transferase

Share to Linkage Disequilibrium

Share to Smoking

Share to South Africa

Source

Open in PubMed Open full text

Identifiers

PMID: 22216261
DOI: 10.1371/journal.pone.0029366
PMCID: PMC3246501

Genes

GSTT1
GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of a deletion of GSTT2B with an altered risk of oesophageal squamous cell carcinoma in a South African population: a case-control study.PMID 22216261Read ↗

Population-specific genetic associations with oesophageal squamous cell carcinoma in South Africa.Semantic proximity Read ↗

The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer.Semantic proximity Read ↗

Distinct genetic association at the PLCE1 locus with oesophageal squamous cell carcinoma in the South African population.Semantic proximity Read ↗

Glutathione S-transferase T1 and M1: gene sequence variation and functional genomics.Semantic proximity Read ↗

Association of cytochrome P450 2E1 genetic polymorphisms with squamous cell carcinoma of the oesophagus.Semantic proximity Read ↗

Pooled analysis indicates that the GSTT1 deletion, GSTM1 deletion, and GSTP1 Ile105Val polymorphisms do not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers.Semantic proximity Read ↗

CYP3A5 genotypes and risk of oesophageal cancer in two South African populations.Semantic proximity Read ↗

Genetic variations in CYP2A6, CYP2E1, GSTM1, GSTT1 genes and the risk of Nasopharyngeal carcinoma in North African population.Semantic proximity Read ↗

MicroRNA polymorphisms and environmental smoke exposure as risk factors for oesophageal squamous cell carcinoma.Semantic proximity Read ↗

Association between GSTT-1 gene deletion and the susceptibility to oral squamous cell carcinoma in cigarette-smoking subjects.Semantic proximity Read ↗

Linkage disequilibrium between two high-frequency deletion polymorphisms: implications for association studies involving the glutathione-S transferase (GST) genes.Semantic proximity Read ↗

Aberrations in the mismatch repair genes and the clinical impact on oesophageal squamous carcinomas from a high incidence area in South Africa.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.