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Article

PNPLA3 polymorphisms and liver aminotransferase levels in a Mexican American population.

Clinical and investigative medicine. Medecine clinique et experimentale - 4 Aug 2012

Li Quan, Qu Hui-Qi, Rentfro Anne R, Grove Megan L, Mirza Shaper, Lu Yang, Hanis Craig L, Fallon Michael B, Boerwinkle Eric, Fisher-Hoch Susan P, McCormick Joseph B

Abstract excerpt

PURPOSE: This study examined genetic associations of patatin-like phospholipase domain containing 3 gene (PNPLA3) polymorphisms and liver aminotransferases in an extensively documented, randomly recruited Mexican American population at high risk of liver disease. METHODS: Two single nucleotide polymorphisms (SNP) in the PNPLA3 gene (i.e., rs738409 and rs2281135) were genotyped in 1532 individuals. Population...

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Source

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Identifiers

PMID: 22863562
DOI: 10.25011/cim.v35i4.17153
PMCID: PMC3441048

Genes

PNPLA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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PNPLA3 polymorphisms and liver aminotransferase levels in a Mexican American population.PMID 22863562Read ↗

Genome‐Wide Association Study Identifies Loci for Liver Enzyme Concentrations in Mexican Americans: The GUARDIAN ConsortiumSemantic proximity Read ↗

Association of PNPLA3 I148M with Liver Disease Biomarkers in Latinos.Semantic proximity Read ↗

More Evidence for the Genetic Susceptibility of Mexican Population to Nonalcoholic Fatty Liver Disease through PNPLA3.Semantic proximity Read ↗

PNPLA3 variation and kidney disease.Semantic proximity Read ↗

PNPLA3 I148M polymorphism is associated with elevated alanine transaminase levels in Mexican Indigenous and Mestizo populations.Semantic proximity Read ↗

Patatin-like phospholipase 3 (rs738409) gene polymorphism is associated with increased liver enzymes in obese adolescents and metabolic syndrome in all ages.Semantic proximity Read ↗

Association between PNPLA3 (rs738409), LYPLAL1 (rs12137855), PPP1R3B (rs4240624), GCKR (rs780094), and elevated transaminase levels in overweight/obese Mexican adults.Semantic proximity Read ↗

Genetic variation in the patatin-like phospholipase domain-containing protein-3 (PNPLA-3) gene in Asian Indians with nonalcoholic fatty liver disease.Semantic proximity Read ↗

Association of HSD17B13 and PNPLA3 With Liver Enzymes and Fibrosis in Hispanic/Latino Individuals of Diverse Genetic Ancestries.Semantic proximity Read ↗

Genetic variants in COL13A1, ADIPOQ and SAMM50, in addition to the PNPLA3 gene, confer susceptibility to elevated transaminase levels in an admixed Mexican population.Semantic proximity Read ↗

Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.Semantic proximity Read ↗

Sex-specific effects of PNPLA3 I148M.Semantic proximity Read ↗

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