Article
More Evidence for the Genetic Susceptibility of Mexican Population to Nonalcoholic Fatty Liver Disease through PNPLA3.
Annals of hepatology - 1 Mar 2018
Chinchilla-López Paulina, Ramírez-Pérez Oscar, Cruz-Ramón Vania, Canizales-Quinteros Samuel, Domínguez-López Aarón, Ponciano-Rodríguez Guadalupe, Sánchez-Muñoz Fausto, Méndez-Sánchez Nahum
Abstract excerpt
BACKGROUND: The gene for patatin-like phospholipase domain containing 3 (PNPLA3) is associated with nonalcoholic fatty liver disease (NAFLD) development. We previously found that Mexican indigenous population had the highest frequency reported of the PNPLA3 148M risk allele. Further, we observed a relationship between M148M genotype with elevated ALT levels in individuals with normal weight, overweight and obese....
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