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Article

Association of PNPLA3 I148M with Liver Disease Biomarkers in Latinos.

Human heredity - 1 Jan 2021

Roe Jonathan D, Garcia Luis A, Klimentidis Yann C, Coletta Dawn K

Abstract excerpt

INTRODUCTION: Liver disease accounts for approximately 2 million deaths per year worldwide. The majority of liver diseases are due to complications of cirrhosis, viral hepatitis, and hepatocellular carcinoma. Increased levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) may indicate liver disease. Moreover, there are additional noninvasive liver fibrosis indices that help to estimate...

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Share to Biomarkers
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Membrane Proteins

Share to Non-alcoholic Fatty Liver Disease

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 34749354
DOI: 10.1159/000520734

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of PNPLA3 I148M with Liver Disease Biomarkers in Latinos.PMID 34749354Read ↗

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Global epidemiology and implications of PNPLA3 I148M variant in MASLD: a systematic review and meta-analysisSemantic proximity Read ↗

Patatin-Like Phospholipase Domain-Containing Protein 3 I148M and Liver Fat and Fibrosis Scores Predict Liver Disease Mortality in the U.S. Population.Semantic proximity Read ↗

The PNPLA3 I148M polymorphism is associated with insulin resistance and nonalcoholic fatty liver disease in a normoglycaemic population.Semantic proximity Read ↗

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I148M variant of PNPLA3 increases the susceptibility to non-alcoholic fatty liver disease caused by obesity and metabolic disorders.Semantic proximity Read ↗

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PNPLA3 polymorphisms and risk of hepatic and extrahepatic outcomes in MASLD: A meta-analysis of observational studies.Semantic proximity Read ↗

Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease.Semantic proximity Read ↗

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