Retrogradely transmitted α-synuclein is taken up by the endophilin-independent endocytosis in the C. elegans neural circuit.

Abstract excerpt

α-Synuclein is a major component of Lewy bodies and Lewy neuritis which are hallmarks of Parkinson's disease, and is known to propagate from cell-to-cell in a prion-like manner. However, the exact mechanism of α-synuclein propagation in cells remains unclear. Despite the increasing number of studies and models of α-synuclein propagation, there is no direct evidence demonstrating whether the propagation is...

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