Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions.

Cell - 30 May 2008

Simon David J, Madison Jon M, Conery Annie L, Thompson-Peer Katherine L, Soskis Michael, Ruvkun Gary B, Kaplan Joshua M, Kim John K

Abstract excerpt

We show that miR-1, a conserved muscle-specific microRNA, regulates aspects of both pre- and postsynaptic function at C. elegans neuromuscular junctions. miR-1 regulates the expression level of two nicotinic acetylcholine receptor (nAChR) subunits (UNC-29 and UNC-63), thereby altering muscle sensitivity to acetylcholine (ACh). miR-1 also regulates the muscle transcription factor MEF-2, which results in altered...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MicroRNAs

Share to Neuromuscular Junction

Share to Nicotinic Agonists

Share to rab3 GTP-Binding Proteins

Share to Receptors, Nicotinic

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 18510933
DOI: 10.1016/j.cell.2008.04.035
PMCID: PMC2553566

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions.PMID 18510933Read ↗

Regulation of retrograde signaling at neuromuscular junctions by the novel C2 domain protein AEX-1.Semantic proximity Read ↗

Neurexin and neuroligin mediate retrograde synaptic inhibition in C. elegans.Semantic proximity Read ↗

A <i>C. elegans</i> genome-wide RNAi screen for altered levamisole sensitivity identifies genes required for muscle functionSemantic proximity Read ↗

The immunoglobulin super family protein RIG-3 prevents synaptic potentiation and regulates Wnt signaling.Semantic proximity Read ↗

Motor Neurons Decode Cholinergic Inputs via Spatially Distinct nAChR Subunits to Drive Locomotion in Drosophila larvaeSemantic proximity Read ↗

The evolutionarily conserved gene LNP-1 is required for synaptic vesicle trafficking and synaptic transmission.Semantic proximity Read ↗

Two populations of heteromeric acetylcholine receptors are present at Caenorhabditis elegans neuromuscular junctions.Semantic proximity Read ↗

The GTPase dMiro is required for axonal transport of mitochondria to Drosophila synapses.Semantic proximity Read ↗

Behavioral impact of neurotransmitter-activated G-protein-coupled receptors: muscarinic and GABAB receptors regulate Caenorhabditis elegans locomotion.Semantic proximity Read ↗

miR-1 coordinately regulates lysosomal v-ATPase and biogenesis to impact proteotoxicity and muscle function during aging.Semantic proximity Read ↗

Sensory regulated Wnt production from neurons helps make organ development robust to environmental changes in C. elegans.Semantic proximity Read ↗

A neuronal acetylcholine receptor regulates the balance of muscle excitation and inhibition in Caenorhabditis elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.