Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

APEX1 Polymorphism and Mercaptopurine-Related Early Onset Neutropenia in Pediatric Acute Lymphoblastic Leukemia.

Cancer research and treatment - 1 Jul 2018

Kim Hyery, Seo Heewon, Park Yoomi, Min Byung-Joo, Seo Myung-Eui, Park Kyung Duk, Shin Hee Young, Kim Ju Han, Kang Hyoung Jin

Abstract excerpt

PURPOSE: Mercaptopurine (MP) is one of the main chemotherapeutics for acute lymphoblastic leukemia (ALL). To improve treatment outcomes, constant MP dose titration is essential to maintain steady drug exposure, while minimizing myelosuppression. We performed two-stage analyses to identify genetic determinants of MP-related neutropenia in Korean pediatric ALL patients. MATERIALS AND METHODS: Targeted sequencing of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child, Preschool
Share to DNA-(Apurinic or Apyrimidinic Site) Lyase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infant

Share to Mercaptopurine

Share to Neutropenia

Share to Odds Ratio

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 28882023
DOI: 10.4143/crt.2017.351
PMCID: PMC6056975

Genes

APEX1
NUDT15
ABCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

APEX1 Polymorphism and Mercaptopurine-Related Early Onset Neutropenia in Pediatric Acute Lymphoblastic Leukemia.PMID 28882023Read ↗

ITPA, TPMT, and NUDT15 Genetic Polymorphisms Predict 6-Mercaptopurine Toxicity in Middle Eastern Children With Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

Optimal predictor for 6-mercaptopurine intolerance in Chinese children with acute lymphoblastic leukemia: NUDT15, TPMT, or ITPA genetic variants?Semantic proximity Read ↗

NUDT15 Pharmacogenetics in Acute Lymphoblastic Leukemia: Synthesizing Progress for Personalized Thiopurine TherapySemantic proximity Read ↗

Implementation of Pharmacogenetics to Individualize Treatment Regimens for Children with Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia.Semantic proximity Read ↗

Association of NUDT15*3 and FPGS 2572C>T Variants with the Risk of Early Hematologic Toxicity During 6-MP and Low-Dose Methotrexate-Based Maintenance Therapy in Indian Patients with Acute Lymphoblastic Leukemia.Semantic proximity Read ↗

Genetic variants of genes involved in thiopurine metabolism pathway are associated with 6-mercaptopurine toxicity in pediatric acute lymphoblastic leukemia patients from EthiopiaSemantic proximity Read ↗

ABCC4 , ITPA , NUDT15 , TPMT and their interaction as genetic predictors of 6-mercaptopurine intolerance in chinese patients with acute lymphoblastic leukemiaSemantic proximity Read ↗

Association between NUDT15 rs116855232T/C Genetic Polymorphism and Mercaptopurine Toxicity in Syrian Children with Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

NUDT15 Polymorphism and Its Association With Mercaptopurine Hematotoxicity in Acute Lymphoblastic Leukemia in Indonesian Children.Semantic proximity Read ↗

Childhood acute lymphoblastic leukemia mercaptopurine intolerance is associated with NUDT15 variants.Semantic proximity Read ↗

Homozygote CRIM1 variant is associated with thiopurine-induced neutropenia in leukemic patients with both wildtype NUDT15 and TPMTSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.