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Article

The catechol-O-methyltransferase Val(158)Met polymorphism modulates fronto-cortical dopamine turnover in early Parkinson's disease: a PET study.

Brain : a journal of neurology - 1 Aug 2012

Wu Kit, O'Keeffe Deirdre, Politis Marios, O'Keeffe Grainne C, Robbins Trevor W, Bose Subrata K, Brooks David J, Piccini Paola, Barker Roger A

Abstract excerpt

Cognitive deficits occur in up to 30% of patients with early Parkinson's disease, some of which are thought to result from dysfunction within the fronto-striatal dopaminergic network. Recently, it has been shown that a common functional polymorphism (Val(158)Met) in the catechol-O-methyltransferase (COMT) gene is associated with changes in executive performance in tasks that have a fronto-striatal basis. This is...

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Identifiers

PMID: 22843413
DOI: 10.1093/brain/aws157

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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