Article
Scanning positional variations in single-nucleotide polymorphism of DNA: an electrochemical study.
The Analyst - 21 Sept 2012
Alam Md Nazmul, Shamsi Mohtashim Hassan, Kraatz Heinz-Bernhard
Abstract excerpt
While there are a number of electrochemical methods reported that enable the detection of single nucleotide mismatches, the determination of mismatch position in a double stranded DNA remains an unsolved challenge. Using a model system, we systematically explored the electrochemical response of all possible positions of single nucleotide mismatches in a set of 25-mer DNA films. These ds-DNA sequences each with a...
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