Article
Detection of single-base mismatch at distal end of DNA duplex by electrochemical impedance spectroscopy.
Biosensors & bioelectronics - 15 Mar 2007
Ito Toshiyuki, Hosokawa Kazuo, Maeda Mizuo
Abstract excerpt
Herein, we report an anomalous electrochemical behavior of surface-bound DNA duplex that has single-base mismatches at its distal end. Single-stranded 15-base DNA was immobilized at its 5'end onto gold electrode surfaces. After hybridization with complementary or mismatched DNA, electrochemical i...
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