Article

Cross-Species Hepatic Metabolism of the Antileishmanial Chalcone NAT22 Generates Metabolites with Enhanced Affinity for the Parasite Target cTXNPx

2026-03-03

Abstract excerpt

<h4>Background: </h4> /Objectives: Human and canine leishmaniasis are neglected diseases with limited therapeutic options. The nitrochalcone NAT22, a high-affinity inhibitor of the essential parasite enzyme tryparedoxin peroxidase (cTXNPx), has emerged as a promising antileishmanial candidate. Interestingly, NAT22 demonstrated superior efficacy when administered orally rather than intralesionally, suggesting metab...

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Literature Corpus work: dd1856ef-df73-5aa0-9852-4a653639efec
DOI: 10.20944/preprints202603.0166.v1

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Cross-Species Hepatic Metabolism of the Antileishmanial Chalcone NAT22 Generates Metabolites with Enhanced Affinity for the Parasite Target cTXNPxDOI 10.20944/preprints202603.0166.v1Read

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