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Sox9 and Sox8 Are Required for Basal Lamina Integrity of Testis Cords and for Suppression of FOXL2 During Embryonic Testis Development in Mice1

27 Jul 2012

Abstract excerpt

The sex-determining gene Sry and its target gene Sox9 initiate the early steps of testis development in mammals. Of the related Sox genes Sox8, Sox9, and Sox10, all expressed during Sertoli cell differentiation, only inactivation of Sox9 before the sex determination stage at Embryonic Day 11.5 (E11.5) causes XY sex reversal, while Sox9 inactivation after this stage has no effect on testis cord differentiation. We...

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PMID: 22837482
DOI: 10.1095/biolreprod.112.101907

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Sox9 and Sox8 Are Required for Basal Lamina Integrity of Testis Cords and for Suppression of FOXL2 During Embryonic Testis Development in Mice1PMID 22837482Read ↗

<i>Sox9</i> in Testis DeterminationSemantic proximity Read ↗

Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degenerationSemantic proximity Read ↗

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SOX Genes and Their Role in Disorders of Sex DevelopmentSemantic proximity Read ↗

Normal Levels of Sox9 Expression in the Developing Mouse Testis Depend on the TES/TESCO Enhancer, but This Does Not Act Alone.Semantic proximity Read ↗

Testis cord differentiation after the sex determination stage is independent of Sox9 but fails in the combined absence of Sox9 and Sox8Semantic proximity Read ↗

Genome-wide identification of Sox8-, and Sox9-dependent genes during early post-natal testis development in the mouse.Semantic proximity Read ↗

Functional analysis of <i>Sox8</i> and <i>Sox9</i> during sex determination in the mouseSemantic proximity Read ↗

Homozygous inactivation of Sox9 causes complete XY sex reversal in mice.Semantic proximity Read ↗

Diverse Regulation but Conserved Function: SOX9 in Vertebrate Sex DeterminationSemantic proximity Read ↗

Analysis of medaka sox9 orthologue reveals a conserved role in germ cell maintenance.Semantic proximity Read ↗

The Sex-Determining Factors SRY and SOX9 Regulate Similar Target Genes and Promote Testis Cord Formation during Testicular DifferentiationSemantic proximity Read ↗

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