A functional polymorphism C-1310G in the promoter region of Ku70/XRCC6 is associated with risk of renal cell carcinoma.

doi:10.1002/mc.21914

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Article

A functional polymorphism C-1310G in the promoter region of Ku70/XRCC6 is associated with risk of renal cell carcinoma.

Molecular carcinogenesis - 1 Oct 2012

Wang Wei, Pan Xuping, Huo Xinying, Yan Fu, Wang Meilin, Wang Dingxian, Gao Yanqin, Cao Qiang, Luo Dewei, Qin Chao, Yin Changjun, Zhang Zhengdong

Abstract excerpt

The DNA repair gene Ku70 plays a key role in the DNA double strand break (DSB) repair system. Defects in DSB repair capacity can lead to genomic instability. We hypothesized that the Ku70 C-1310G polymorphism (rs2267437) was associated with risk of renal cell carcinoma (RCC). We genotyped the Ku70 C-1310G polymorphism in a case-control study of 620 patients and 623 controls in a Chinese population and assessed...

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Identifiers

PMID: 22593040
DOI: 10.1002/mc.21914

Genes

XRCC6

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