Article
Reprogramming of trophoblast stem cells into pluripotent stem cells by Oct4.
Stem cells (Dayton, Ohio) - 1 May 2011
Wu Tong, Wang Haitao, He Jing, Kang Lan, Jiang Yonghua, Liu Jinchao, Zhang Yu, Kou Zhaohui, Liu Lijun, Zhang Xuehong, Gao Shaorong
Abstract excerpt
ESCs and trophoblast stem (TS) cells are both derived from early embryos, yet these cells have distinct differentiation properties. ESCs can differentiate into all three germ layer cell types, whereas TS cells can only differentiate into placental cells. It has not been determined whether TS cells can be converted into ES-like pluripotent stem (PS) cells. Here, we report that overexpression of a single...
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