Article
His595Tyr polymorphism in the methionine synthase reductase (MTRR) gene is associated with pancreatic cancer risk.
Gastroenterology - 1 Aug 2008
Ohnami Shumpei, Sato Yasunori, Yoshimura Kimio, Ohnami Sumiko, Sakamoto Hiromi, Aoki Kazunori, Ueno Hideki, Ikeda Masafumi, Morizane Chigusa, Shimada Kazuaki, Sakamoto Yoshihiro, Esaki Minoru, Saito Ikuo, Hirose Hiroshi, Saito Daizo, Sugimura Haruhiko, Kosuge Tomoo, Okusaka Takuji, Yoshida Teruhiko
Abstract excerpt
BACKGROUND & AIMS: This study attempts to elucidate a part of the genetic predisposition to the sporadic invasive ductal adenocarcinoma of the pancreas focusing on the genes implicated in the gene-environment interactions in carcinogenesis. METHODS: First, 227 single nucleotide polymorphisms (SNPs) of 46 genes were genotyped on 198 cases and 182 controls. The SNPs, which showed a significant association, were...
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