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Article

Systematic analysis of pyrazinamide-resistant spontaneous mutants and clinical isolates of Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 1 Oct 2012

Stoffels Karolien, Mathys Vanessa, Fauville-Dufaux Maryse, Wintjens René, Bifani Pablo

Abstract excerpt

Pyrazinamide (PZA) is a first-line antitubercular drug known for its activity against persistent Mycobacterium tuberculosis bacilli. We set out to systematically determine the PZA susceptibility profiles and mutations in the pyrazinamidase (pncA) gene of a collection of multidrug-resistant tuberculosis (MDR-TB) clinical isolates and PZA-resistant (PZA(r)) spontaneous mutants. The frequency of acquired resistance...

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Identifiers

PMID: 22825123
DOI: 10.1128/AAC.05385-11
PMCID: PMC3457413

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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