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Article

Selection of in vitro mutants of pyrazinamide-resistant Mycobacterium tuberculosis.

International journal of antimicrobial agents - 1 Oct 2002

Bamaga M, Wright D J M, Zhang H

Abstract excerpt

Mutations within the pncA gene coding for pyrazinamidase of Mycobacterium tuberculosis can cause pyrazinamide (PZA) resistance. The effect of drug concentrations on PZA resistance in a clinical isolate of M. tuberculosis was studied in vitro. Serial passage at gradually increased concentrations of PZA from 200 to 500 microg/ml was performed using BACTEC radiometric method. Thirteen in vitro-selected variant...

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Source

Identifiers

PMID: 12385684
DOI: 10.1016/s0924-8579(02)00182-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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