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Article

Stimulation of histone deacetylase activity by metabolites of intermediary metabolism.

The Journal of biological chemistry - 14 Sept 2012

Vogelauer Maria, Krall Abigail S, McBrian Matthew A, Li Jing-Yu, Kurdistani Siavash K

Abstract excerpt

Histone deacetylases (HDACs) function in a wide range of molecular processes, including gene expression, and are of significant interest as therapeutic targets. Although their native complexes, subcellular localization, and recruitment mechanisms to chromatin have been extensively studied, much less is known about whether the enzymatic activity of non-sirtuin HDACs can be regulated by natural metabolites. Here,...

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Identifiers

PMID: 22822071
DOI: 10.1074/jbc.M112.362467
PMCID: PMC3442532

Genes

HDAC1
HDAC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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