Article
Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4.
Hepatology (Baltimore, Md.) - 1 Sept 2013
Ellinghaus David, Folseraas Trine, Holm Kristian, Ellinghaus Eva, Melum Espen, Balschun Tobias, Laerdahl Jon K, Shiryaev Alexey, Gotthardt Daniel N, Weismüller Tobias J, Schramm Christoph, Wittig Michael, Bergquist Annika, Björnsson Einar, Marschall Hanns-Ulrich, Vatn Morten, Teufel Andreas, Rust Christian, Gieger Christian, Wichmann H-Erich, Runz Heiko, Sterneck Martina, Rupp Christian, Braun Felix, Weersma Rinse K, Wijmenga Cisca, Ponsioen Cyriel Y, Mathew Christopher G, Rutgeerts Paul, Vermeire Séverine, Schrumpf Erik, Hov Johannes R, Manns Michael P, Boberg Kirsten M, Schreiber Stefan, Franke Andre, Karlsen Tom H
Abstract excerpt
UNLABELLED: Approximately 60%-80% of patients with primary sclerosing cholangitis (PSC) have concurrent ulcerative colitis (UC). Previous genome-wide association studies (GWAS) in PSC have detected a number of susceptibility loci that also show associations in UC and other immune-mediated diseases. We aimed to systematically compare genetic associations in PSC with genotype data in UC patients with the aim of...
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