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Article

TGR5 sequence variation in primary sclerosing cholangitis.

Digestive diseases (Basel, Switzerland) - 1 Jan 2011

Hov Johannes R, Keitel Verena, Schrumpf Erik, Häussinger Dieter, Karlsen Tom H

Abstract excerpt

TGR5, the G-protein-coupled bile acid receptor 1 (GPBAR1), has been linked to inflammatory pathways and homeostasis, and could therefore be involved in primary sclerosing cholangitis (PSC), a chronic inflammatory bile duct disease associated with ulcerative colitis (UC). In addition, the TGR5 gene is localized at chromosome 2q35, close to a genetic variant associated with both PSC and UC in recent genome-wide...

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Topics

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Share to Base Sequence
Share to Cholangitis, Sclerosing
Share to Colitis, Ulcerative

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to Genetic Predisposition to Disease

Share to Genetic Variation

Share to Liver Diseases and Immunity

Share to Receptors, G-Protein-Coupled

Source

Identifiers

PMID: 21691110
DOI: 10.1159/000324138

Genes

GPBAR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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