Article
Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9.
Hepatology (Baltimore, Md.) - 1 Jun 2011
Janse Marcel, Lamberts Laetitia E, Franke Lude, Raychaudhuri Soumya, Ellinghaus Eva, Muri Boberg Kirsten, Melum Espen, Folseraas Trine, Schrumpf Erik, Bergquist Annika, Björnsson Einar, Fu Jingyuan, Jan Westra Harm, Groen Harry J M, Fehrmann Rudolf S N, Smolonska Joanna, van den Berg Leonard H, Ophoff Roel A, Porte Robert J, Weismüller Tobias J, Wedemeyer Jochen, Schramm Christoph, Sterneck Martina, Günther Rainer, Braun Felix, Vermeire Severine, Henckaerts Liesbet, Wijmenga Cisca, Ponsioen Cyriel Y, Schreiber Stefan, Karlsen Tom H, Franke Andre, Weersma Rinse K
Abstract excerpt
UNLABELLED: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by inflammation and fibrosis of the bile ducts. Both environmental and genetic factors contribute to its pathogenesis. To further clarify its genetic background, we investigated susceptibility loci recently identified for ulcerative colitis (UC) in a large cohort of 1,186 PSC patients and 1,748 controls. Single...
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