Article
Memory CD4+ T cells protect against influenza through multiple synergizing mechanisms.
The Journal of clinical investigation - 1 Aug 2012
McKinstry K Kai, Strutt Tara M, Kuang Yi, Brown Deborah M, Sell Stewert, Dutton Richard W, Swain Susan L
Abstract excerpt
Memory CD4+ T cells combat viral infection and contribute to protective immune responses through multiple mechanisms, but how these pathways interact is unclear. We found that several pathways involving memory CD4+ T cells act together to effectively clear influenza A virus (IAV) in otherwise unprimed mice. Memory CD4+ T cell protection was enhanced through synergy with naive B cells or CD8+ T cells and maximized...
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