Article
Immune signatures of protective spleen memory CD8 T cells.
Scientific reports - 24 Nov 2016
Brinza Lilia, Djebali Sophia, Tomkowiak Martine, Mafille Julien, Loiseau Céline, Jouve Pierre-Emmanuel, de Bernard Simon, Buffat Laurent, Lina Bruno, Ottmann Michèle, Rosa-Calatrava Manuel, Schicklin Stéphane, Bonnefoy Nathalie, Lauvau Grégoire, Grau Morgan, Wencker Mélanie, Arpin Christophe, Walzer Thierry, Leverrier Yann, Marvel Jacqueline
Abstract excerpt
Memory CD8 T lymphocyte populations are remarkably heterogeneous and differ in their ability to protect the host. In order to identify the whole range of qualities uniquely associated with protective memory cells we compared the gene expression signatures of two qualities of memory CD8 T cells sharing the same antigenic-specificity: protective (Influenza-induced, Flu-TM) and non-protective (peptide-induced, TIM)...
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