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Article

Enhanced cartilage formation by inhibiting cathepsin K expression in chondrocytes expanded in vitro.

Biomaterials - 1 Oct 2012

Zhang Yan, Li Jie, Zhu Ji, Zhou Guangdong, Zhang Wen Jie, Cao Yilin, Liu Wei

Abstract excerpt

Although engineered cartilage has great potential in cartilage regeneration and reconstruction, dedifferentiation of chondrocytes during in vitro expansion remains a technical bottleneck in the clinical application. To overcome the problem, a gene modification approach was developed to knock-down the key gene involving dedifferentiation of human chondrocytes. A microarray assay revealed 84 up-regulated genes and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22818652
DOI: 10.1016/j.biomaterials.2012.06.070

Genes

CTSK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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