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Article

Enhanced cartilage formation by inhibiting cathepsin K expression in chondrocytes expanded in vitro.

Biomaterials - 1 Oct 2012

Zhang Yan, Li Jie, Zhu Ji, Zhou Guangdong, Zhang Wen Jie, Cao Yilin, Liu Wei

Abstract excerpt

Although engineered cartilage has great potential in cartilage regeneration and reconstruction, dedifferentiation of chondrocytes during in vitro expansion remains a technical bottleneck in the clinical application. To overcome the problem, a gene modification approach was developed to knock-down...

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Source

Identifiers

PMID: 22818652
DOI: 10.1016/j.biomaterials.2012.06.070

Genes

CTSK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22818652-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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