Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

STARS is essential to maintain cardiac development and function in vivo via a SRF pathway.

PloS one - 1 Jan 2012

Chong Nelson W, Koekemoer Andrea L, Ounzain Samir, Samani Nilesh J, Shin Jordan T, Shaw Stanley Y

Abstract excerpt

BACKGROUND: STARS (STriated muscle Activator of Rho Signaling) is a sarcomeric protein expressed early in cardiac development that acts as an acute stress sensor for pathological remodeling. However the role of STARS in cardiac development and function is incompletely understood. Here, we investigated the role of STARS in heart development and function in the zebrafish model and in vitro. METHODOLOGY AND...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Heart
Share to Expressed Sequence Tags
Share to Heart Ventricles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microfilament Proteins

Share to Models, Animal

Share to Serum Response Factor

Share to Zebrafish

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22815879
DOI: 10.1371/journal.pone.0040966
PMCID: PMC3399798

Genes

SRF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

STARS is essential to maintain cardiac development and function in vivo via a SRF pathway.PMID 22815879Read ↗

Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activitySemantic proximity Read ↗

SRF: a seriously responsible factor in cardiac development and diseaseSemantic proximity Read ↗

Regulation of cardiac growth and development by SRF and its cofactors.Semantic proximity Read ↗

Role of the serum response factor in regulating contractile apparatus gene expression and sarcomeric integrity in cardiomyocytes.Semantic proximity Read ↗

Regulation of STARS and its downstream targets suggest a novel pathway involved in human skeletal muscle hypertrophy and atrophySemantic proximity Read ↗

Restricted inactivation of serum response factor to the cardiovascular system.Semantic proximity Read ↗

Identification of direct serum-response factor gene targets during Me2SO-induced P19 cardiac cell differentiation.Semantic proximity Read ↗

Sin3a Associated Protein 130kDa, sap130, plays an evolutionary conserved role in zebrafish heart developmentSemantic proximity Read ↗

Stem cells and their derivatives can bypass the requirement of myocardin for smooth muscle gene expression.Semantic proximity Read ↗

Splicing factor Srsf5 deletion disrupts alternative splicing and causes noncompaction of ventricular myocardiumSemantic proximity Read ↗

Hesr2 knockout mice develop aortic valve disease with advancing age.Semantic proximity Read ↗

A dual role of the GTPase Rac in cardiac differentiation of stem cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.