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Article

Splicing factor Srsf5 deletion disrupts alternative splicing and causes noncompaction of ventricular myocardium

10 Sept 2021

Abstract excerpt

The serine/arginine-rich (SR) family of splicing factors plays important roles in mRNA splicing activation, repression, export, stabilization, and translation. SR-splicing factor 5 (SRSF5) is a glucose-inducible protein that promotes tumor cell growth. However, the functional role of SRSF5 in tissue development and disease remains unknown. Here, Srsf5 knockout ( Srsf5 −/− ) mice were generated using CRISPR-Cas9....

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PMID: 34622152
DOI: 10.1016/j.isci.2021.103097

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