Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional epistatic interaction between rs6046G>A in F7 and rs5355C>T in SELE modifies systolic blood pressure levels.

PloS one - 1 Jan 2012

El Shamieh Said, Ndiaye Ndeye Coumba, Stathopoulou Maria G, Murray Helena A, Masson Christine, Lamont John V, Fitzgerald Peter, Benetos Athanase, Visvikis-Siest Sophie

Abstract excerpt

BACKGROUND: Although numerous genetic studies have been performed, only 0.9% of blood pressure phenotypic variance has been elucidated. This phenomenon could be partially due to epistatic interactions. Our aim was to identify epistatic interaction(s) associated with blood pressure levels in a pre-planned two-phase approach. METHODS AND RESULTS: In a discovery cohort composed of 3,600 French individuals, we found...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Blood Pressure

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to E-Selectin

Share to Epistasis, Genetic

Share to Factor VII

Share to Gene Expression Regulation

Share to Polymorphism, Single Nucleotide

Share to Systole

Source

Open in PubMed Open full text

Identifiers

PMID: 22815813
DOI: 10.1371/journal.pone.0040777
PMCID: PMC3399862

Genes

NAMPT
SELE
DEFA1
FPR1
ICAM1
SELL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional epistatic interaction between rs6046G>A in F7 and rs5355C>T in SELE modifies systolic blood pressure levels.PMID 22815813Read ↗

Epistatic study reveals two genetic interactions in blood pressure regulation.Semantic proximity Read ↗

Effects of three candidate genes on prevalence and incidence of hypertension in a Caucasian population.Semantic proximity Read ↗

Genome-Wide Interaction Analysis With DASH Diet Score Identified Novel Loci for Systolic Blood Pressure.Semantic proximity Read ↗

Association of ATP1B1, RGS5 and SELE polymorphisms with hypertension and blood pressure in African-Americans.Semantic proximity Read ↗

Risk Effects of rs1799945 Polymorphism of the HFE Gene and Intergenic Interactions of GWAS-Significant Loci for Arterial Hypertension in the Caucasian Population of Central Russia.Semantic proximity Read ↗

Epistatic interaction between alpha- and gamma-adducin influences peripheral and central pulse pressures in white Europeans.Semantic proximity Read ↗

Polymorphisms of inflammatory markers and risk of essential hypertension in Tatars from Russia.Semantic proximity Read ↗

Polymorphisms in alpha 7 nicotinic acetylcholine receptor gene, CHRNA7, and its partially duplicated gene, CHRFAM7A, associate with increased inflammatory response in human peripheral mononuclear cells.Semantic proximity Read ↗

Stromelysin-1 (MMP-3) gene 5A/6A promoter polymorphism is associated with blood pressure in a community population.Semantic proximity Read ↗

Influence of Smoking Status and Intensity on Discovery of Blood Pressure Loci Through Gene-Smoking Interactions.Semantic proximity Read ↗

Suppressor of cytokine signaling 3 A+930-->G (rs4969168) polymorphism is associated with apolipoprotein A1 and low-density lipoprotein cholesterol.Semantic proximity Read ↗

Role of the adducin family genes in human essential hypertension.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.