Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of three candidate genes on prevalence and incidence of hypertension in a Caucasian population.

Journal of hypertension - 1 Aug 2001

Staessen J A, Wang J G, Brand E, Barlassina C, Birkenhäger W H, Herrmann S M, Fagard R, Tizzoni L, Bianchi G

Abstract excerpt

BACKGROUND: The genes encoding angiotensin converting enzyme (ACE, I/D), alpha-adducin (ADD, Gly460Trp) and aldosterone synthase (AS, -344C/T) share the potential of influencing blood pressure (BP) via sodium homeostasis. However, most studies in humans focused on single-gene effects and disregarded epistasis, the suppression or potentiation of a gene by other non-allelic genes. METHODS: We studied the singular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calmodulin-Binding Proteins
Share to Cross-Sectional Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP11B2

Share to Epistasis, Genetic

Share to Hypertension

Share to Incidence

Share to Peptidyl-Dipeptidase A

Share to White People

Source

Identifiers

PMID: 11518842
DOI: 10.1097/00004872-200108000-00002

Genes

ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of three candidate genes on prevalence and incidence of hypertension in a Caucasian population.PMID 11518842Read ↗

Blood pressure in relation to three candidate genes in a Chinese population.Semantic proximity Read ↗

Role of the adducin family genes in human essential hypertension.Semantic proximity Read ↗

A systematic review of nonsynonymous single nucleotide polymorphisms in the renin-angiotensin-aldosterone system.Semantic proximity Read ↗

Familial Analysis of Epistatic and Sex-Dependent Association of Genes of the Renin-Angiotensin-Aldosterone System and Blood Pressure.Semantic proximity Read ↗

Genetic polymorphism of the renin-angiotensin-aldosterone system and arterial hypertension in the Italian population: the GENIPER Project.Semantic proximity Read ↗

Polymorphisms of the insertion / deletion ACE and M235T AGT genes and hypertension: surprising new findings and meta-analysis of data.Semantic proximity Read ↗

The epistasis between vascular homeostasis genes is apparent in essential hypertension.Semantic proximity Read ↗

Are genetic polymorphisms in the renin-angiotensin-aldosterone system associated with essential hypertension? Evidence from genome-wide association studies.Semantic proximity Read ↗

Reevaluation of the association of seven candidate genes with blood pressure and hypertension: a replication study and meta-analysis with a larger sample size.Semantic proximity Read ↗

Synergistic effect of alpha-adducin and ACE genes causes blood pressure changes with body sodium and volume expansion.Semantic proximity Read ↗

Gene variants of the renin-angiotensin system and hypertension: from a trough of disillusionment to a welcome phase of enlightenment?Semantic proximity Read ↗

Angiotensin-converting enzyme I/D and alpha-adducin Gly460Trp polymorphisms: from angiotensin-converting enzyme activity to cardiovascular outcome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.